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The Coronavirus and College Basketball's Postseason

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  • Catgrad7072
    Senior Member
    • Oct 2014
    • 322

    #616
    Originally posted by Matt Dillon
    I've always heard that the only stupid question is the one not asked, so here goes. I can understand the testing part, to see if hydro is an effective method of treatment. The part I don't understand is it's already been approved for treatment of malaria so why does the FDA have to approve it again as a treatment for Covid-19?
    Good question.

    I know that many drugs have off-label uses.

    Viagra, for example, was originally developed as a heart medication. .......................

    Comment

    • Spiritof96
      Senior Member
      • Oct 2014
      • 13503

      #617
      Originally posted by Matt Dillon
      I've always heard that the only stupid question is the one not asked, so here goes. I can understand the testing part, to see if hydro is an effective method of treatment. The part I don't understand is it's already been approved for treatment of malaria so why does the FDA have to approve it again as a treatment for Covid-19?
      I don't know for sure, but what I do know is that drug prescriptions lean on "Number needed to treat" NNT (the number of people that need to receive the treatment for 1 person to receive a benefit) vs. Number Needed to Harm (How many people need to be exposed to the treatment to harm 1 person). An approved drug has that worked out for its designated application but will not have those numbers established for a new treatment.

      The NNH and NNT of some common medications are rather dicey. For example, you are more likely to get diabetes from an anti-statin drug than prevent 1 heart attack. NNT of 60 for heart attack and 268 for stroke and for cardiovascular disease death the NNT is infinity; meaning that many people need to take the drug for 5 years to prevent 1 of the conditions. The NNH for anti-statins new-onset diabetes if 50. Meaning for every 50 people who receive the treatment 1 will develop diabetes.

      I'm not a Physician, so YMMV.
      Originally posted by John Stuart Mill
      ​He who knows only his own side of the case knows little of that... He must be able to hear them from persons who actually believe them...he must know them in their most plausible and persuasive form.
      Originally posted by Robert “Hoot” Gibson
      No matter how bad things may seem, you can always make them worse.
      RIP: Charlie Munger​

      Comment

      • Dwight Schrute
        Senior Member
        • Oct 2014
        • 18716

        #618
        Originally posted by Catgrad7072

        Good question.

        I know that many drugs have off-label uses.

        Viagra, for example, was originally developed as a heart medication. .......................
        Talk about a happy accident!

        Comment

        • Joneslab
          Senior Member
          • Oct 2014
          • 39604

          #619
          I read that somebody who was taking the malaria thing on his own died today. Probably not wise to use politicians as physicians and best wait to see if this thing works.

          This seemed to be, all in all, a better day around the world. I want to SERIOUSLY knock on wood after saying that, but there was some good news coming from certain pockets of the world today. I hope to God that we can get through another week and maybe see some real progress to what we're doing.

          In other news is that my wife has bought carpet, a couch, and a massive bed in the last 24 hours. Prayers up for our bank account.

          Comment

          • Dwight Schrute
            Senior Member
            • Oct 2014
            • 18716

            #620
            I bought a router and a monitor last week in prep for my extended work from home.

            After a week I may never go back.

            Comment

            • ralph helm
              Senior Member
              • Nov 2014
              • 565

              #621
              Hope this stay in place gets over with soon or I might have to cheat a little to get to some place that sells BEER!!!!!!!

              Comment

              • ralph helm
                Senior Member
                • Nov 2014
                • 565

                #622
                Folks---Take a chill pill-----this is the USA---the greatest country in the world---we have been through other crisises before--worse than this--we will live through it& look back in a year or two & chuckle about it!!!!!

                Comment

                • bigbluebob
                  Senior Member
                  • Jan 2015
                  • 125

                  #623
                  AMEM Ralph!
                  God, Family, Kentucky Basketball

                  Comment

                  • Catgrad7072
                    Senior Member
                    • Oct 2014
                    • 322

                    #624
                    Originally posted by Dwight Schrute

                    Talk about a happy accident!
                    No kidding!

                    My doc said that the patients / test subjects didn't want to give up their 'heart medicine' at the end of the trial period. The rest, as they say is history.

                    Comment

                    • justford
                      Senior Member
                      • Oct 2014
                      • 4669

                      #625
                      Originally posted by Dwight Schrute

                      Talk about a happy accident!
                      With a happy ending 😂

                      Comment

                      • Matt Dillon
                        Administrator
                        • Oct 2014
                        • 49618

                        #626
                        Originally posted by ralph helm
                        Folks---Take a chill pill-----this is the USA---the greatest country in the world---we have been through other crisises before--worse than this--we will live through it& look back in a year or two & chuckle about it!!!!!
                        If you mean, by "we", the nation then I might agree. If you are talking about Americans that are living today, then no. Not unless there are people living who are old enough to remember WWII when things, like gasoline, were rationed. As far as people chuckling about it, it certainly won't be the ones who are suffering loss of income and witnessing the illness and/or death of friends and loved ones.
                        Philippians 4:11-4:13

                        Comment

                        • 40bill
                          Senior Member
                          • Nov 2014
                          • 8451

                          #627
                          On a lighter note....if there can be one....

                          The US government has said no prayer in schools.
                          Now that kids are home, politicians are asking each week for days of prayer.

                          Comment

                          • 40bill
                            Senior Member
                            • Nov 2014
                            • 8451

                            #628
                            On a serious note....we all take a hit. Personally, my 401k is now a 200.5 k heading towards a 100.25 K. The economic impact will last far longer than the virus itself, if it follows the growth/decay path of China and South Korea.
                            The world will change. Maybe a little, maybe a whole lot.
                            We all will have to adapt. How we handle that adaptation will be the story.
                            Personally, I miss shaking hands and hugs from family and church. I dont miss sports as much as I'd thought.
                            i have found putting myself on 72 hour social distancing from any news other than Beshears announcements to be beneficial.
                            AND....learning what I THOUGHT were necessities were not so much.

                            Comment

                            • Lighthouse
                              Gone But Never Forgotten
                              • Oct 2014
                              • 35962

                              #629
                              Originally posted by 40bill
                              On a serious note....we all take a hit. Personally, my 401k is now a 200.5 k heading towards a 100.25 K. The economic impact will last far longer than the virus itself, if it follows the growth/decay path of China and South Korea.
                              The world will change. Maybe a little, maybe a whole lot.
                              We all will have to adapt. How we handle that adaptation will be the story.
                              Personally, I miss shaking hands and hugs from family and church. I dont miss sports as much as I'd thought.
                              i have found putting myself on 72 hour social distancing from any news other than Beshears announcements to be beneficial.
                              AND....learning what I THOUGHT were necessities were not so much.
                              Personally I spend a lot more time in Prayer for all our Leaders as they make decisions to help everyone get through this. Also for those sick with the virus, my Family, my Friends including every WCN member and their Families. Always lot's to be on our knees about, especially now.
                              Last edited by Lighthouse; 03-24-2020, 03:08 PM.
                              John 3:3

                              Comment

                              • Catatonic
                                Senior Member
                                • Jul 2016
                                • 2913

                                #630
                                Originally posted by 40bill
                                On a lighter note....if there can be one....

                                The US government has said no prayer in schools.
                                Now that kids are home, politicians are asking each week for days of prayer.
                                Prayer has always been allowed in schools. What you are talking about is forced organized prayer, which is unconstitutional.

                                I'm still out here working, I feel like Mad Max driving through ghost towns....

                                Comment

                                 

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                                The Coronavirus and College Basketball's Postseason

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